Spectroscopy with iMQCs

In Vivo Spectroscopy

In vivo spectroscopy can be used to obtain chemical signatures of a diseased organ, much as conventional NMR can be used to determine the chemical components in a test tube. We are developing iMQC methods that allow us to gain this information with higher spectral resolution than conventional methods.

Spinlocked Spectroscopy

All NMR signals typically decay quickly in vivo, but this decay is a particularly keen obstacle for iMQC signals, whose growth is prematurely clipped by T2 relaxation. We can extended the buildup time of iMQC signals using spinlocking pulses, which change the relaxation mechanism and slow the relaxation rate.

iMQCs with Magic Angle Spinning

In an intermolecular multiple quantum experiment the signal is largely limited by sample inhomogeneity which limits the data acquisition time and produces line broadening. Resolution enhancement can be obtained in principle spinning the sample at the magic angle (MAS).

Increasing iMQC Signal In Vivo

In vivo, signals from intermolecular multiple quantum coherences (iMQCs) reach very diminished signal intensities due to transverse relaxation. However, with simple modifications to the standard CRAZED sequence, the signal can be increased beyond the T2 limit.