Representative Publications
Hamburger JB, Hoertz AJ, Lee A, Senturia RJ, McCafferty DG, Loll PJ A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface Proc. Natl. Acad. Sci.. Epub Aug 3.
Gaweska H, Henderson Pozzi M, Schmidt DM, McCafferty DG, Fitzpatrick PF Use of pH and kinetic isotope effects to establish chemistry as rate-limiting in oxidation of a peptide substrate by LSD1 Biochemistry . 2009 Jun 16;48(23):5440-5.
Kudryavtsev KV, Bentley ML, McCafferty DG, Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of Staphylococcus aureus sortase SrtA isoform Bioorganic and Medicinal Chemistry . 2009 April 1;17(7):2886-93
Deshmukh HS, Hamburger JB, Ahn SH, McCafferty DG, Yang SR, Fowler VG Jr. The Critical Role of NOD2 in Regulating the Immune Response to Staphylococcus aureus. Infect Immun . 2009Apr;77(4):1376-82.
Race PR, Bentley ML, Melvin JA, Crow A, Hughes RK, Smith WD, Sessions RB, Kehoe MA, McCafferty DG, Banfield MJ. Crystal structure of S. pyogenes sortase A: Implications for sortase mechanism. J Biol Chem. Epub 2009 Jan 6.
Bentley ML, Lamb EC, McCafferty DG. Mutagenesis Studies of Substrate Recognition and Catalysis in the Sortase A Transpeptidase from Staphylococcus aureus. J Biol Chem. 2008 May 23;283(21):14762-71. Epub 2008 Mar 28.
Gooden DM, Schmidt DM, Pollock JA, Babadi AM, McCafferty DM. Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B. Bioorg Med Chem Lett. 2008 May 15;18(10):3047-51. Epub 2008 Jan 8.
Frankel BA,Tong Y, Bentley ML, Fitzgerald MC, McCafferty DG.Mutational Analysis of Active Site Residues in the Staphylococcus aureus Transpeptidase SrtA. Biochemistry. 2007 Jun 19;46(24):7269-78. Epub 2007 May 23.
Schmidt DM, McCafferty DG. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry. 2007 Apr 10;46(14):4408-16. Epub 2007 Mar 17.
Bentley ML, Gaweska H, Kielec JM, McCafferty DG. Engineering the substrate specificity of staphylococcus aureus sortase A: The beta 6/beta 7 loop from SrtB confers NPQTN recognition to SrtA. J Biol Chem 2007 Mar 2;282(9):6571-81. Epub 2007 Jan 2.
McCafferty DG. Crossing a biological velvet rope. ACS Chem Biol 2006 1(6):339-40
Lee MG, Wynder C, Schmidt DM, McCafferty DG, Shiekhattar R. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol 2006 13:563-7
Frankel BA, Kruger RG, Robinson DE, Kelleher NL, McCafferty DG. 2005. Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism. Biochemistry 2005 44:11188-200,
Kruger RG, Barkallah S, Frankel BA, McCafferty DG. Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics. Bioorg Med Chem 2004 12:3723-9
Frankel BA, McCafferty DG. Profiling natural product biosynthesis. Chem Biol 2004 11:290-1
Striplin DR, Reece SY, McCafferty DG, Wall CG, Friesen DA, Erickson BW, Meyer TJ. 2004. Solvent dependence of intramolecular electron transfer in a helical oligoproline assembly. J Am Chem Soc 2004 126:5282-91
Frankel BA, Bentley M, Kruger RG, McCafferty DG. Frankel BA, Bentley M, Kruger RG, McCafferty DG. 2004. Vinyl sulfones: inhibitors of SrtA, a transpeptidase required for cell wall protein anchoring and virulence in Staphylococcus aureus. J Am Chem Soc 2004 126:3404-5
Loyola A, He S, Oh S, McCafferty DG, Reinberg D. 2004. Techniques used to study transcription on chromatin templates. Methods Enzymol 2004 377:474-99
Kruger RG, Dostal P, McCafferty DG. Development of a high-performance liquid chromatography assay and revision of kinetic parameters for the Staphylococcus aureus sortase transpeptidase SrtA. Anal Biochem 326:42-8
Kruger RG, Otvos B, Frankel BA, Bentley M, Dostal P, McCafferty DG. Analysis of the substrate specificity of the Staphylococcus aureus sortase transpeptidase SrtA.Biochemistry 2004 43:1541-51
He S, Bauman D, Davis JS, Loyola A, Nishioka K, Gronlund JL, Reinberg D, Meng F, Kelleher N, McCafferty DG. Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proc Natl Acad Sci U S A 2003 100:12033-8
Kapustin GV, Fejer G, Gronlund JL, McCafferty DG, Seto E, Etzkorn FA. Phosphorus-based SAHA analogues as histone deacetylase inhibitors. Org Lett 2003 5:3053-6
McCafferty DG, Cudic P, Frankel BA, Barkallah S, Kruger RG, Li W. Chemistry and biology of the ramoplanin family of peptide antibiotics. Biopolymers 2002 66:261-84
Huang CY, He S, DeGrado WF, McCafferty DG, Gai F. Light-induced helix formation. J Am Chem Soc 2002 124:12674-5
Kruger RG, Dostal P, McCafferty DG. An economical and preparative orthogonal solid phase synthesis of fluorescein and rhodamine derivatized peptides: FRET substrates for the Staphylococcus aureus sortase SrtA transpeptidase reaction. Chem Commun (Camb) 2002 2092-3
Cudic P, Behenna DC, Kranz JK, Kruger RG, Wand AJ, Veklich YI, Weisel JW, McCafferty DG. Functional analysis of the lipoglycodepsipeptide antibiotic ramoplanin. Chem Biol 2002 9:897-906
Cudic P, Kranz JK, Behenna DC, Kruger RG, Tadesse H, Wand AJ, Veklich YI, Weisel JW, McCafferty DG. Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation. Proc Natl Acad Sci U S A 2002. 99:7384-9
Cudic P, Behenna DC, Yu MK, Kruger RG, Szewczuk LM, McCafferty DG. Synthesis of P(1)-Citronellyl-P(2)-alpha-D-pyranosyl pyrophosphates as potential substrates for the E. coli undecaprenyl-pyrophosphoryl-N-acetylglucoseaminyl transferase MurG. Bioorg Med Chem Lett 2001 11:3107-10
McCafferty DG, Cudic P, Yu MK, Behenna DC, Kruger R. McCafferty DG, Cudic P, Yu MK, Behenna DC, Kruger R. 1999. Synergy and duality in peptide antibiotic mechanisms. Curr Opin Chem Biol 1999 3:672-80
Lessard IA, Pratt SD, McCafferty DG, Bussiere DE, Hutchins C, Wanner BL, Katz L, Walsh CT. Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. Chem Biol1998 5:489-504
McCafferty DG, Lessard IA, Walsh CT. Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. Biochemistry 1997. 36:10498-505
McCafferty DG, Friesen DA, Danielson E, Wall CG, Saderholm MJ, Erickson BW, Meyer TJ. Photochemical energy conversion in a helical oligoproline assembly. Proc Natl Acad Sci U S A 1996. 93:8200-4