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CURRICULUM VITAE
Barbara Ramsay Shaw
Department of Chemistry
Duke University
Durham, NC 27708-0346
(919)660-1551 (Office) FAX (919) 660-1618
(919)493-9494 (Home)
Present Position: Professor of Chemistry, Duke University
Academic History:
1965 A. B. in Chemistry
Bryn Mawr College, Bryn Mawr, Pennsylvania
1966-1972 Graduate Student in Physical Chemistry at the University of Washington,
Seattle, Washington 1966-1970, and at Princeton University,
Princeton, New Jersey 1971-72 (where I completed my thesis
research as a visiting pre-doctoral student in the laboratory of
Prof. Walter Kauzmann)
1973 Ph.D. University of Washington, Seattle Dissertation: (with Prof. J.
Michael Schurr) "The Synthesis and Association Reaction of
Collagen Model Polypeptides: (Pro-Pro-Gly)n"
1973-1975 Postdoctoral Fellow, Department of Biochemistry and Biophysics, Oregon
State University, Corvallis, Oregon (with Prof. K. E. Van Holde)
"Isolation and Characterization of Core Particles in Chromatin"
1976-1981 Assistant Professor of Chemistry, Duke University and Camille and Henry
Dreyfus Foundation Teacher-Scholar
1982-1992 Associate Professor of Chemistry, Duke University
1992-present Professor of Chemistry, Duke University
Member: Genetics Program; Integrated Toxicology Program; Developmental, Cell, and
Molecular Biology Program; Pharmacology Program; Molecular Biophysics Program;
Marine Biomedical Center; Duke Cancer Center
Awards and Fellowships:
Faculty Research Career Development Award-American Cancer Society, 1986-1990
Camille and Henry Dreyfus Foundation Teacher-Scholar Award, 1976-1981
Areas of Special Interest:
Boronated Nucleic Acids, DNA Structure, and Antisense Agents
Modification, Mutagenesis, and Reactivity of DNA
Histones, Nucleosomes, and Chromatin Structure
DNA-Protein Interactions
National Service:
Member of study sections: NSF - Biochemistry, 1985
American Cancer Society - Nuclear Proteins, 1986-90
NIH - Chemical Pathology, 1995-97
Editorial Board: Antisense & Nucleic Acid Drug Development, 1996-99
Chairman, Symposium on Molecular and Chemical Approaches to Genetic Toxicology, Duke University, March 20, 1991
National Organizing Committee for Boron USA. Member, 1994-99
Council for Gordon Research Conferences. Member, 1996-97
Chairman: Gordon Conference on Purines and Pyrimidines, 1997
Visiting Associate, Committee on Professional Training, American Chemical Society, 1982-90
PUBLICATIONS:
1. B. R. Shaw, J. L. Corden, C. G. Sahasrabuddhe and K. E. Van Holde
"Chromatographic Separation of Chromatin Subunits".
Biochem. Biophys. Res. Commun. 61, 1193-2000 (1974).
2. K. E. Van Holde, C. G. Saharasbuddhe and B. R. Shaw
"A Model for Particulate Structure in Chromatin".
Nucleic Acids Res. 1, 1579-1586 (1974).
3. K. E. Van Holde, C. G. Sahasrabuddhe, B. R. Shaw, E. F. J. van Bruggen and A. C. Arnberg
"Electron Microscopy of Chromatin Subunit Particles".
Biochem. Biophys. Res. Commun. 60, 1365-1370 (1974).
4. B. R. Shaw and J. M. Schurr
"The Association Reaction of Collagen Model Polypeptides (Pro-Pro-Gly)n".
Biopolymers 14, 1951-1985 (1975).
5. K. E. Van Holde, B. R. Shaw, D. Lohr, T. M. Herman and R. T. Kovacik
"Subunit Structure of Chromatins".
Proc. of the 10th Annual Fed. Eur. Biochem. Soc. Conf., Paris, pp. 57-72 (1975).
6. B. R. Shaw, T. M. Herman, R. T. Kovacic, G. S. Beaudreau and K. E. Van Holde
"Analysis of the Subunit Structure in Chicken Erythrocyte Chromatin".
Proc. Nat. Acad. Sci., USA 73, 503-507 (1976).
7. B. Ramsay-Shaw and K. S. Schmitz
"Reanalysis of Histone-Induced Conformational Changes
in DNA Determined by Quasielastic Light Scattering".
Biopolymers 15, 2313-2315 (1976).
8. B. R. Shaw and K. S. Schmitz
"Quasielastic Light Scattering by Biopolymers. Conformation of Chromatin Multimers".
Biochem. Biophys. Res. Commun. 73, 224-232 (1976).
9. B. R. Shaw, T. M. Herman, R. T. Kovacic and K. E. Van Holde
"Nucleoprotein Core Particles in Chromatin Subunits:
Existence of a Complex of Eight Histones and 140 Nucleotide Pairs of DNA".
Molecular Mechanisms in the Control of Gene Expression,
eds., D. P. Nierlich, W. J. Rutter and C. F. Fox, Academic Press, pp. 13-20 (1976).
10. K. E. Van Holde, B. Ramsay Shaw, K. Tatchell, J. Pardon, D. Worchester, J. Wooley and B. Richards
"The Structural Subunits of Chromatin".
The Molecular Biology of the Mammalian Genetic Apparatus, Volume I,
eds., P. O. P. Ts'o, Academic Press, pp. 239-254 (1977).
11. K. S. Schmitz and B. Ramsay Shaw
"Hydrodynamic Evidence in Support of Spacer Regions in Chromatin".
Science 197, 661-663 (1977).
12. K. S. Schmitz and B. Ramsay Shaw
"Chromatin Conformation:
A Systematic Analysis of Helical Parameters from Hydrodynamic Data".
Biopolymers 16, 2619-2633 (1977).
13. R. Rill, B. Ramsay Shaw and K. E. Van Holde
"Isolation and Characterization of Chromatin Subunits".
Methods in Cell Biology, Volume 18, (Chromatin and Chromosomal Protein Research III)
eds., G. Stein, J. Stein and L. J. Kleinsmith, Academic Press, pp. 69-103 (1978).
14. B. Ramsay Shaw and R. G. Richards
"Preparation and Analysis of Core Particles and Nucleosomes:
A Convenient Method for Studying the Protein Composition of Nucleosomes Using Protamine-Release into Triton-Acid-Urea Gels".
Chromatin Structure and Function from Nucleosome to Nuclei, NATO Advanced Study Institutes Series,
ed., C. Nicolini, Plenum Press, N.Y., Volume 21a, pp. 125-236 (1979).
15. B. Ramsay Shaw and K. S. Schmitz
"Conformation of Polynucleosomes in Low Ionic Strength Solution".
Chromatin Structure and Function from Nucleosome to Nuclei, NATO Advanced Study Institutes Series,
ed., C. Nicolini, Plenum Press, N.Y., Volume 21b, pp. 427-440 (1979).
16. B. Ramsay Shaw, G. Cognetti, W. B. Sholes and R. R. Richards
"Shift in Nucleosome Populations during Embryogenesis:
Microheterogeneity in Nucleosomes during Development of the Sea Urchin Embryo".
Biochemistry 20, 4971-4978 (1981).
17. G. Cognetti and B. Ramsay Shaw
"Structural Differences in the Chromatin from Compartmentalized Cells of the Sea Urchin Embryo:
Differential Nuclease Accessibility of Micromere Chromatin".
Nucleic Acids Res. 9, 5609-5621 (1981).
18. Randall G. Richards and B. Ramsay Shaw
"In Situ Protamine-Release of Acid Soluble Nuclear Proteins:
A Versatile Sample Preparation Method For the Electrophoretic Analysis of Nucleosomal Proteins On Acid/Urea-Based Gels".
Analyt. Biochem. 121, 69-82 (1982).
19. D. G. Graham, D. Carter Anthony, K. Boekelheide, N. A. Maschmann, R. G. Richards, J. W. Wolfram and B. Ramsay Shaw
"Studies of the Molecular Pathogenesis of Hexane Neuropathy.
II. Evidence that Pyrrole Derivitization of Lysinyl Residues Leads to Protein Cross-Linking".
Toxicology and Applied Pharmacology 64, 415-422 (1982).
20. S. A. M. Chambers, J. P. Vaughn and B. Ramsay Shaw
"The Shortest Nucleosomal Repeat Lengths during Sea Urchin Development are Found in Two-Cell Embryos".
Biochemistry 22, 5626-5631 (1983).
21. D. E. Mold, J. Weingart, J. Assaraf, D. B. Lubahn, D. N. Kelner, B. R. Shaw and K. S. McCarty, Sr.
"Silver Staining of Histones in Triton-Acid-Urea Gels".
Analyt. Biochem. 135, 44-47 (1983).
22. R. G. Richards and B. Ramsay Shaw
"Temporal Changes in Nucleosome Populations during Early Sea Urchin Development".
Biochemistry 23, 2095-2102 (1984).
23. S. A. M. Chambers and B. Ramsay Shaw
"Levels of Histone H4 Diacetylation Decrease Dramatically
During Sea Urchin Embryonic Development and Correlate with Cell Doubling Rate".
J. Biol. Chem. 259, 13458-13463 (1984).
24. S. A. M. Chambers, G. Cognetti and B. Ramsay Shaw
"Diffusible Factors Are Responsible for Differences in Nuclease Sensitivity
Among Chromatins Originating from Different Cell Types".
Exp.Cell Res. 154, 213-223 (1984).
25. L. D. Williams and B. Ramsay Shaw
"Protonated Base Pairs Explain the Ambiguous Base Pairing Properties of O6Methylguanine".
Proc. Natl. Acad. Sci., USA 84, 1779-1783 (1987).
26. L. D. Williams, B. Chawla and B. Ramsay Shaw
"The Hydrogen Bonding of Cytosine with Guanine:
Calorimetric and 'H-NMR Analysis of the Molecular Interactions of Nucleic Acid Bases".
Biopolymers 26, 591-603 (1987).
27. L. C. Sowers, B. Ramsay Shaw, M. L. Veigl and W. David Sedwick
"DNA Base Modification: Ionized Base Pairs and Mutagenesis".
Mutation Research 177, 201-218 (1987).
28. S. A. M. Chambers and B. Ramsay Shaw
"Histone Modifications Accompanying the Onset of Developmental Commitment
in the 16-Cell Stage Sea Urchin Embryo".
Dev. Biol. 124, 523-531 (1987).
29. L. C. Sowers, B. Ramsay Shaw and W. D. Sedwick
"Base Stacking and Molecular Polarizability:
Effect of the Methyl Group in the 5-Position of Pyrimidines".
Biochem. Biophys. Res. Commun. 148, 790-794 (1987).
30. L. C. Sowers, W. D. Sedwick and B. Ramsay Shaw
"Hydrolysis of N3-Methyl-2'-Deoxycytidine:
Model Compound for Reactivity of Protonated Cytosine Residues in DNA".
Mutation Research 215, 131-138 (1989).
31. A. Sood, B. F. Spielvogel and B. Ramsay Shaw
"Boron-Containing Nucleic Acids: Synthesis of Cyanoborane Adducts of 2'-Deoxynucleosides".
J. Am. Chem. Soc. 111, 9234-9235 (1989).
32. N. G. Williams, L. D. Williams and B. Ramsay Shaw
"Dimers, Trimers and Tetramers of Cytosine with Guanine".
J. Am. Chem. Soc. 111, 7205-7209 (1989).
33. L. D. Williams, N. G. Williams and B. Ramsay Shaw
"In a Model C:G Base Pair, One Amino Group Rotates and the Other Does Not".
J. Am. Chem. Soc. 112, 829-833 (1990).
34. L. A. Frederico, T. A. Kunkel and B. Ramsay Shaw
"A Sensitive Genetic Assay for the Detection of Cytosine Deamination:
Determination of Rate Constants and the Activation Energy".
Biochemistry 29, 2532-2537 (1990).
35. A. F. Sood, B. Ramsay Shaw and B. F. Spielvogel
"Boron-Containing Nucleic Acids.
2. Synthesis of Oligodeoxynucleoside Boranophosphates".
J. Am. Chem. Soc. 112, 9000-9001 (1990).
36. B. F. Spielvogel, A. Sood, B. Ramsay Shaw and I. H. Hall
"From Boron Analogues of Amino Acids to Boronated DNA:
Potential New Pharmaceuticals and Neutron Capture Agents".
Pure & Appl. Chem. 63, 415-418 (1991).
37. B. F. Spielvogel, A. Sood, B. Ramsay Shaw, I. H. Hall, R. G. Fairchild, B. H. Laster and C. Gordon
"Boron Containing Nucleic Acids".
Progress in Neutron Capture Therapy for Cancer,
ed., B. J Allen, Plenum Press, pp. 211-213 (1992).
38. A. Sood, B. F. Spielvogel, B. Ramsay Shaw, L. D. Carlton, B. S. Burnham and I H. Hall
"The Synthesis and Antineoplastic Activity of 2'-Deoxynucleoside-Cyanoboranes
in Murine and Human Culture Cells".
Anticancer Research 12, 335-344 (1992).
39. I. H. Hall, E. S. Hall, L. K. Chi, B. Ramsay Shaw, A. Sood and B. F. Spielvogel
"Antineoplastic Activity of Boron-Containing Thymidine Nucleosides in Tmolt3 Leukemic Cells".
AntiCancer Research 12, 1091-1098 (1992).
40. R. A. MacPhail, L. D. Williams, D. A. Jones and B. Ramsay Shaw
"Variable Temperature Infrared Spectroscopy of Cytosine-Guanine Base Pairs:
Tautomerism versus Polarization".
J. Biomolecular Structure and Dynamics 9, 881-898 (1992).
41. J. Tomasz, B. Ramsay Shaw, K. Porter, B. F. Spielvogel and A. Sood
"5'-P-Borane-Substituted Thymidine Monophosphate and Triphosphate".
Angewandte Chemie 31, 1373-1375 (1992).
42. A. Sood, B. Ramsay Shaw, B. F. Spielvogel, E. S. Hall, L. K Chi and I.R. Hall
"The Synthesis and Anti-Neoplastic Activity of
N2-Isobutyryl-2'-deoxyguanosine-N7-Cyanoborane Derivatives".
Die Pharmazie 47, 833-838 (1992).
43. B. Ramsay Shaw, J. Madison, A. Sood, and B. F. Spielvogel,
"Oligonucleoside Boranophosphate (Borane Phosphonate) Oligomers".
in Protocols for Oligonucleotides and Analogs: Synthesis and Properties,
ed., S. Agrawal, Methods in Molecular Biology Series, Vol. 20. Humana Press, Inc , Clifton, N.J., pp. 225-243 (1993).
44. B.F. Spielvogel, A. Sood, J. Tomasz, B. R. Shaw, S. Karthikeyan, W. Powell, B. Laster, R. M. Brugger and J. Coderre
"Boronated Peptides and Nucleic Acid Compounds for NCT".
in Advances in Neutron Capture Therapy,
eds. R. F. Barth and A. H. Soloway. Plenum Press, NY, pp. 361-365 (1993).
45. B. F. Spielvogel, A. Sood, W. Powell, J. Tomasz, K. Porter and B. Ramsay Shaw
"Chemical and Enzymatic Incorporation of Boron into DNA".
in Advances in Neutron Capture Therapy,
eds. R. F. Barth and A. H. Soloway. Plenum Press, NY, pp. 389-393 (1993).
46. H. Chen and B. Ramsay Shaw
"Kinetic Parameters for Bisulfite-Induced Cytosine Deamination in Single-Stranded DNA".
Biochemistry 32, 3535-3539 (1993).
47. I. H. Hall, B. S. Burnham, K. G. Rajendran, S. Y. Chen, A. Sood, B. F. Spielvogel and B. Ramsay Shaw
"Hypolipidemic Activity of Boronated Nucleosides and Nucleotides in Rodents".
Biomed .& Pharmacother. 47, 79-87 (1993).
48. R. Moyer, U. A. Stewart, D. Briley, A. Johnsen and B. Ramsay Shaw
"Echinomycin, a Bis-intercalator, Induces C-->T Mutations via Cytosine Deamination".
Mutation Research 288, 291-300 (1993).
49. L. Frederico, T. A. Kunkel and B. Ramsay Shaw
"Cytosine Deamination in Mismatched Base Pairs".
Biochemistry 32, 6523-6530 (1993).
50. H. Chen and B. Ramsay Shaw
"Bisulfite Induces Tandem Double CC>TT Mutations in Double-Stranded DNA:
2. Kinetics of Deamination".
Biochemistry 33, 4121-4129 (1994).
51. B. S. Burnham, S. Y. Chen, K.G. Rajendran, A. Sood, B. F. Spielvogel, B. Ramsay Shaw, and I. H. Hall
"The Synthesis of Amine-Borane Adducts of Cyclohexylamine, Toluidine, and 3'-Amino
dideoxynucleosides and Evaluation of their Pharmacological Activity".
in Current Topics in the Chemistry of Boron, Proceedings of the Eighth International Meeting on Boron Chemistry,
ed. G.W. Kabalka. The Royal Society of Chemistry, Cambridge, U.K., pp. 189-192 (1994).
52. B. F. Spielvogel, A. Sood, B. Ramsay Shaw and I. H. Hall
"Synthesis of Boron Analogues of Biomolecules as Potential New Pharmaceuticals".
in Current Topics in the Chemistry of Boron, Proceedings of the Eighth International Meeting on Boron Chemistry,
ed. G.W. Kabalka. The Royal Society of Chemistry, Cambridge, U.K., pp. 193-198 (1994).
53. B. Ramsay Shaw
"Induced Deamination of Cytosine: Effect of Secondary Structure and Other Factors".
in Structural Biology: The State of the Art, Vol. 2,
eds. R.H. Sarma and M.H. Sarma. Adenine Press, NY. pp. 367-378 (1994).
54. K. G. Rajendran, B. S. Burnham, S. Y. Chen, A. Sood, B. F. Spielvogel, B. Ramsay Shaw and I. H. Hall
"Anti-Inflammatory and Anti-Osteoporotic Activities of
Base-Boronated Nucleosides and Phosphate-Boronated Nucleotides in Rodents".
J. Pharmaceutical Sciences 83, 1391-1395 (1994).
55. M. Zottola, L. G. Pedersen, P. Singh and B. Ramsay Shaw
"Borohydrides as Novel Hydrogen-Bond Acceptors".
in Modeling the Hydrogen Bond, Proceedings from American Chemical Society Symposia Series
No. 569, Computers in Chemistry, ed. D. A. Smith. American Chemical Society, Washington, DC. pp. 277-285 (1994).
56. K. Porter, J. Tomasz, F. Huang, A. Sood and B. Ramsay Shaw
"N7-Cyanoborane-2'-Deoxyguanosine 5'-Triphosphate is a Good Substrate for DNA Polymerases".
Biochemistry 34, 11963-11969 (1995).
57. H. Li, K. Porter, F. Huang, and B. Ramsay Shaw
"Boron-containing Oligodeoxyribonucleotide 14-mer Duplexes: Enzymatic Synthesis and Melting Studies".
Nucleic Acids Research 23, 4495-4501 (1995).
58. P. Singh, M. Zottola, F. Huang, B. Ramsay Shaw, and L.G. Pedersen
"2'-Deoxy cytidine-N3-cyanoborane Monohydrate".
Acta Crystallographica C52, 694-696 (1996).
59. K. Merchant, H. Chen, T. C. Gonzalez, L.K. Keefer, and B. Ramsay Shaw
"Deamination of DNA Cytosine Residues in Aerobic Nitric Oxide Solution
at Micromolar Total NO Exposures".
Chemical Research in Toxicology, 9, 891-896 (1996).
60. H. Li, C. Hardin, and B. Ramsay Shaw
"Hydrolysis of Thymidine Borano-Monophosphate and
Stepwise Deuterium Substitution of the Borane Hydrogens: 31P and 11B NMR Studies".
Journal of the American Chemical Society 118, 6606-6614 (1996).
61. W. Peng and B. Ramsay Shaw
"Accelerated Deamination of Cytosine Residues in UV-Induced
Cyclobutane Pyrimidine Dimers Leads to CC > TT Transitions".
Biochemistry 35, 10172-10181 (1996).
62. A. Hasan, H. Li, J. Tomasz, and B. Ramsay Shaw
"Base-Boronated Dinucleotides:
Synthesis and Effect of N7-Cyanoborane Substitution on the Base Protons".
Nucleic Acids Resarch 24, 2150-2157 (1996).
63. Q. Gao, A. Sood, B. Ramsay Shaw, and L.D. Williams
"2'-Deoxycytidine-N3-cyanoborane".
Acta Crystallogr., Sect. C: Cryst. Struct. Commun. c52, 1823-1825 (1996).
64. K.W. Porter, J. D. Briley, and B. Ramsay Shaw
"Direct PCR Sequencing with Boronated Nucleotides".
Nucleic Acids Research 25, 1611-1617 (1997).
65. H. Li, F. Huang, and B. Ramsay Shaw
"Conformational Studies of Dithymidine Boranophosphate Diastereoisomers".
Bioorganic and Medicinal Chemistry 5, 787-796 (1997).
66. D. Sergueev, A. Hasan, M. Ramaswamy and B. Ramsay Shaw
"Boranophosphate Oligonucleotides: New Synthetic Approaches".
Nucleosides and Nucleotides 16, 1533-1538 (1997).
67. A. Hasan and B. Ramsay Shaw
"Oligonucleotides Containing N7-Cyanoborane-2'-deoxyguanosine".
Nucleosides and Nucleotides 16, 1539-1542 (1997).
68. A. Hasan, J. Tomasz and B. Ramsay Shaw
"Studies on Base-Boronated Oligonucleotides:
The Incompatibility of DMT and Cyanoborane Groups during Oligonucleotide Synthesis".
Bioconjugate Chemistry 8, 813-818 (1997).
69. K. He, A. Hasan and B. Ramsay Shaw
"The Synthesis of Ribonucleoside 5'-O-(alpha-P-Boranotriphosphates),
Separation of Diastereomers and Incorporation by RNA Polymerases".
Symposium on RNA Biology II: Tool & Target, in Nucleic Acids Symposium Series No. 36,
Oxford University Press, p 159 (1997).
70. B. Krzyzanowska, K. He, A. Hasan and B. Ramsay Shaw
"A Convenient Synthesis of 2'-Deoxyribonucleoside 5'-(alpha-P-Borano)triphosphates".
Tetrahedron 54, 5119-5128 (1998).
71. K. He, A. Hasan, Bozenna Krzyzanowska and B. Ramsay Shaw
"Synthesis and Separation of Diastereomers of Ribonucleoside 5'-(alpha-P-Borano)triphosphates".
Journal of Organic Chemistry 63(17) , 5769-5773 (1998).
72. J. S. Summers, D. Roe, P. D. Boyle, M. Colvin, B. Ramsay Shaw
"Structural Studies of a Borane Modified Phosphate Diester Linkage:
Ab initio Calculations on the Dimethylboranophosphate Anion,
and the Single Crystal X-ray Structure of its Diisopropylammonium Salt".
Inorganic Chemistry 37(17), 4158-4159 (1998).
73. D.S. Sergueev and B. Ramsay Shaw
"H-Phosphonate Approach for Solid-Phase Synthesis of
Boranophosphate Oligodeoxyribonucleotides and their Characterization".
J. Amer. Chem. Soc. 120(37), 9417-9427 (1998).
74. Z. Sergueeva, D.S. Sergueev and B. Ramsay Shaw
"Synthesis of Dithymidine Boranophosphates via Stereospecific
Boronation of H-phosphonate Diesters and Assignment of Their Configuration".
Tetrahedron Lett. 40, 2041-2044 (1999).
75. V. Rait and B. Ramsay Shaw
"Boranophosphates Support the RNase H Cleavage of Polyribonucleotides".
Antisense & Nucleic Acid Drug Development 9, 53-60 (1999).
76. K. He, K. W. Porter, A. Hasan, J. D. Briley and B. Ramsay Shaw
"Synthesis of 5-Substituted 2'-Deoxycytidine 5'-(alpha-P-Borano)triphosphates,
their Incorporation into DNA and Effects on Exonuclease".
Nucleic Acids Research 27, 1788-1794 (1999).
77. K. He, D. Sergueev, Z. Sergueeva and B. Ramsay Shaw
"Synthesis of Diuridine 3',5'-Boranophosphate: H-Phosphonate Approach."
Tetrahedron Letters 40, 4601-4604 (1999).
78. J. Lin and B. Ramsay Shaw
"Synthesis and Properties of a Novel Phosphodiester Analogue, Nucleoside Boranophosphorothioate".
Chemical Communications 1517-1518 (1999).
79. V. Rait, D.S. Sergueev , J. Summers, K. He, F. Huang, B.Krzyzanowska and B. Ramsay Shaw
"Boranophosphate Nucleic Acids - A Versatile DNA Backbone".
Nucleosides and Nucleotides 18, 1379-1380 (1999).
80. K. He and B. Ramsay Shaw
"Diastereomers of 5'-O-adenosyl 3'-O-uridyl Boranophosphate [Up(BH3)A]: Synthesis and Nuclease Resistant Property"
Nucleic Acids Symposium Series No. 41, Oxford Univ. Press, Oxford, UK pp. 99-100 (1999).
81. Shaw, B. R.; Sergueev, D.; He, K. Z.; Porter, K.; Summers, J.; Sergueeva, Z.; and Rait, V.
"Boranophosphate Backbone: A Mimic of Phosphodiesters, Phosphorothioates, and Methylphosphonates"
Methods in Enzymology: Antisense Technology 313, 226-57 (2000).
82. Hughes, J.; Astriab, A.; Yoo, H.; Alahari, S.; Liang, E.; Sergueev, D.; Shaw, B. R.; and Juliano, R. L.
"In vitro Transport and Delivery of Antisense Oligonucleotides"
Methods in Enzymology: Antisense Technology 313, 342-58 (2000).
83. Sergueeva, Z. A.; D. S. Sergueev, A. A. Ribeiro, J. S. Summers, B. Ramsay Shaw
"Individual Isomers of Dinucleoside Boranophosphates as Synthons for Incorporation into Oligonucleotides. Synthesis and Configurational Assignment"
Perspectives in Nucleoside and Nucleic Acid Chemistry, eds. M. Volkan Kisakurek and Helmut Rosemeyer, Verlag Helvetica Chimica Acta, Zurich pp. 109-124 (2000).
84. Lin, J. L.; K. He, and B. Ramsay Shaw
"Synthesis of Boron-containing ADP and GDP Analogues: Nucleoside 5'-(alpha-P-Borano)diphosphates"
Perspectives in Nucleoside and Nucleic Acid Chemistry, eds. M. Volkan Kisakurek and Helmut Rosemeyer, Verlag Helvetica Chimica Acta, Zurich pp. 125-130 (2000).
85. Sergueeva, Z. A.; Sergueev, D. S.; and Shaw, B. R.
"Rapid and selective reduction of amide group by borane-amine complexes in acyl protected nucleosides"
Nucleosides Nucleotides & Nucleic Acids 19, 275-82 (2000).
86. Astriab-Fisher, A.; Sergueev, D. S.; Fisher, M.; Shaw, B. R.; and Juliano, R. L.
"Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates"
Biochemical Pharmacology 60, 83-90 (2000).
87. Shaw, B. Ramsay; D. S. Sergueev, Z. A. Sergueeva, K. W. Porter, V. K. Rait, J. S. Summers, K. He, and J.-L. Lin
"Boronated Nucleic Acid Mimics: Antisense and DNA Chip Applications"
Antisense and Nucleic Acid Drug Development 10, 131-132 (2000).
88. Sergueeva, Z. A.; Sergueev, D. S.; Ribeiro, A. A.; Summers, J. S.; and Shaw, B. R.
"Individual isomers of dinucleoside boranophosphates as synthons for incorporation into oligonucleotides:
Synthesis and configurational assignment"
Helvetica Chimica Acta 83, 1377-91 (2000).
89. Lin, J. L.; He, K. Z.; and Shaw, B. R.
"Synthesis of boron-containing ADP and GDP analogues: Nucleoside 5'-(P-alpha-boranodiphosphates)"
Helvetica Chimica Acta 83, 1392-97 (2000).
90. Lin, J. L.; and Shaw, B. R.
"Synthesis of a boron analogue of glucose-conjugated nucleoside diphosphate: nucleoside alpha-P-boranodiphosphoglucose"
Tetrahedron Letters 41, 6701-04 (2000).
91. Lin, J. L.; and Shaw, B. R.
"Synthesis of a novel triphosphate analogue: nucleoside alpha-P-borano, alpha-P-thiotriphosphate"
Chemical Communications, 2115-16 (2000).
92. He, K. Z.; and Shaw, B. R.
"Synthesis and separation of diastereomers of uridine 2', 3'-cyclic boranophosphate"
Bioorganic & Medicinal Chemistry Letters 11, 615-17 (2001).
93. Lin, J. L.; He, K. Z.; and Shaw, B. R.
"Novel 3', 5'-cyclic nucleotide analogue: Adenosine 3', 5'-cyclic boranomonophosphate"
Organic Letters 3, 795-97 (2001).
94. Summers, J. S.; and Shaw, B. R.
"Boranophosphates as mimics of natural phosphodiesters in DNA"
Current Medicinal Chemistry 8, 1147-55 (2001).
95. Lin, J. L.; and Shaw, B. R.
"Synthesis of a novel nucleic acid mimic: P-boranomethylphosphonate"
Nucleosides Nucleotides & Nucleic Acids 20, 1325-28 (2001).
96. Lin, J. L.; Porter, K. W.; and Shaw, B. R.
"Synthesis and properties of novel triphosphate analogues: Ribonucleoside and deoxyribonucleoside (alpha-P-borano, alpha-P-thio)triphosphates"
Nucleosides Nucleotides & Nucleic Acids 20, 1019-23 (2001).
97. Sergueeva, Z. A.; Sergueev, D. S.; and Shaw, B. R.
"Borane-amine complexes - Versatile reagents in the chemistry of nucleic acids and their analogs"
Nucleosides Nucleotides & Nucleic Acids 20, 941-45 (2001).
98. Sergueev, D. S.; Sergueeva, Z. A.; and Shaw, B. R.
"Synthesis of oligonucleoside boranophosphates via an H-phosphonate method without nucleobase protection"
Nucleosides Nucleotides & Nucleic Acids 20, 789-95 (2001).
99. Lin, J. L.; and Shaw, B. R.
"Synthesis of new classes of boron-containing nucleotides"
Nucleosides Nucleotides & Nucleic Acids 20, 587-96 (2001).
100. Summers, J. S.; Hoogstraten, C. G.; Britt, R. D.; Base, K.; Shaw, B. R.; Ribeiro, A. A.; and Crumbliss, A. L.
"P-31 NMR probes of chemical dynamics: Paramagnetic relaxation enhancement of the H-1 and P-31 NMR resonances of methyl phosphite and methylethyl phosphate anions by selected metal complexes"
Inorganic Chemistry 40, 6547-54 (2001).
101. Lato, S. M.; Ozerova, N. D. S.; He, K. Z.; Sergueeva, Z.; Shaw, B. R.; and Burke, D. H.
"Boron-Containing Aptamers to ATP"
Nucleic Acids Research 30, 1401-07 (2002).
102. Li, P.; and Shaw, B. R.
"Synthesis of Prodrug Candidates: Conjugates of Amino Acid with Nucleoside Boranophosphate"
Organic Letters 4, 2009-12 (2002).
103. Fisher, A. A.; Ye, D. J.; Sergueev, D. S.; Fisher, M. H.; Shaw, B. R.; and Juliano, R. L.
"Evaluating the Specificity of Antisense Oligonucleotide Conjugates - a DNA Array Analysis"
Journal of Biological Chemistry 277, 22980-84 (2002).
104. Crow, S. D. G.; Bailly, C.; Garbay-Jaureguiberry, C.; Roques, B.; Shaw, B. R.; and Waring, M. J.
"DNA Sequence Recognition by the Antitumor Drug Ditercalinium"
Biochemistry 41, 8672-82 (2002).
105. Astriab-Fisher, A.; Sergueev, D.; Fisher, M.; Shaw, B. R.; and Juliano, R. L.
"Conjugates of Antisense Oligonucleotides with the Tat and Antennapedia Cell-Penetrating Peptides: Effects on Cellular Uptake, Binding to Target Sequences, and Biologic Actions"
Pharmaceutical Research 19, 744-54 (2002).
106. Li, P.; and Shaw, B. R.
"Synthesis of Nucleoside 3', 5'-Cyclic Boranophosphorothioate, a New Type of Cyclic Nucleotide"
Chemical Communications, 2890-91 (2002).
107. Shaw, B. R.; Wan, J.; Wang. X.; Dobrikov, M.; He, K.; Porter, K.; Lin, J. L.; Rait, V.; Sergueev, D.; and Sergueeva, Z.
"Reading and Writing Genetic Information with Boranophosphate (Borane Phosphate) Mimics of Nucleotides, DNA and RNA"
in Chemistry of Nucleic Acid Components, ed. Z. Tocik and M. Hocek, Academy of Sciences of the Czeck Republic, Prague, Collection Symposium Series 5, 169-80 (2002).
108. Dobrikov, M. I.; Grady, K. M.; and Shaw, B. R.
"Introduction of the alpha-P-Borano-Group into Deoxynucleoside Triphosphates Increases their Selectivity to HIV-1 Reverse Transcriptase Relative to DNA Polymerases"
Nucleosides Nucleotides & Nucleic Acids 22(3), 275-82 (2003).
109. Li, P.; Dobrikov, M. I.; Liu, H.; and Shaw, B. R.
"Synthesis of Acyclothymidine Triphosphate and alpha-P-Borano-triphosphate and their Substrate Properties with Retroviral Reverse Transcriptase"
Organic Letters 5, 2401-03 (2003).
110. Li, P.; and Shaw, B. R.
"One-Pot Synthesis of an AZT Boranophosphate Conjugated with Tyrosine: A Potential Prodrug Candidate"
Nucleosides Nucleotides & Nucleic Acids 22(5-8), 699-701 (2003).
111. Wang, X.; Dobrikov, M. I.; Sergueev, D.; and Shaw, B. R.
"RNase H Activation by Stereoregular Boranophosphate Oligonucleotide"
Nucleosides Nucleotides & Nucleic Acids 22(5-8), 1151-53 (2003).
112. Dobrikov, M. I.; Sergueev, Z.; and Shaw, B. R.
"Incorporation of (alpha-P-Borano)-2'-3'-dideoxycytidine 5'-Triphosphate into DNA by Drug-Resistant MMLV Reverse Transcriptase and Taq DNA Polymerase"
Nucleosides Nucleotides & Nucleic Acids 22(5-8), 1651-55 (2003).
113. Shaw, B. R.; Dobrikov, M. I.; Sergueev, D.; Sergueev, Z.; Wan, J.; Wang, X.; He, K.; Porter, K.; Li, P.; and Lin, J.-L.
"Reading, Writing, and Modulating Genetic Information with Boranophosphate Mimics of Nucleotides, DNA, and RNA"
in Therapeutic Oligonucleotides: Antisense, RNAi, Triple Helix, DNA Decoys, and DNA Chips ed Y.S. Cho-Chung, A. M. Gewirtz, and C. A. Stein. Annals of the New York Academy of Sciences 1002, 12-29 (2003).