Dr. Akhremitchev research interests are in experimental biophysical chemistry and physical chemistry.
Biophysical research focuses on understanding the physico-chemical mechanisms of the initial stages of amyloid fibril formation and structural properties of fibrillar aggregates. Single-molecule force spectroscopy and AFM nanoindentation techniques are employed to investigate forming of supramolecular structures at different levels of assembly: from single molecules to formed fibrils.
Research in physical chemistry concentrates on experimental quantification of the potential of mean force responsible for hydrophobic interactions. In these studies "hydrophobic bonds" between single non-polar molecules is ruptured by application of external force and kinetic parameters of dissociation are obtained by statistical data analysis.
The single-molecule research further develops methodology of the dynamic force spectroscopy to uncover information that is not available by other techniques. Of related interest is the examination of the systematic errors in force spectroscopy development of approaches to extract the non-biased kinetic parameters from the measurements.