Polymer-Supported Scavengers for Organic Synthesis

Liu Deng

Chemistry 373 Seminar

11:50 a.m.11/20/02, room 103

ABSTRACT:  Recent advances in polymeric supported scavenger reagents in organic synthesis will be reviewed. These reagents have been mainly used to simplify purification of solution phase reactions when solid phase synthesis is not accessible or requires too much time and cost. General concepts of nucleophilicelectrophilic and ionic scavengers will be described. Examples of multistep syntheses employing solid-supported scavengers will be presented. One example of their application in solid phase synthesis will also be given.

BIBLIOGRAPHY:

1. Booth, R. J.; Hodges, J. C. J. Am. Chem. Soc.1997, 119, 4882.

2. Kaldor, S. W.; Fritz, J. E.; Tang, J.; McKinney, E. R. Bio. Med. Chem. Lett.1996, 6, 3041.

3. ChataignerI.Gennari, C.; Piarulli, U.; Ceccarelli, S. AngewChem. Int. Ed. 2000, 39, 916.

4. Plante, O.; Palmacci, E. R.; Seeberger, P. H. Science2001, 291, 1523.

5. Palmacci, E. R.; Hewitt, M. C.; Seeberger, P. H. AngewChem. Int. Ed. 2001, 40, 4433.

6. Falchi, A.; Taddei, M. Org. Lett.2000, 2, 3429.

7. Guisado, O.; Martinez, S.; Pastor, J. Tetrahedron Lett.2002, 43, 7105.

8. Yu, Z.;  Alesso, S.;  Pears, D.;  Worthington, P. A.;  Luke, R. W.;  Bradley, M.Tetrahedron Lett.2000,  41,  8963.