Mammalian Iron Transport (Transferrin)

Objective: To investigate the mechanisms of Fe binding and release from the C and N terminal lobes of transferrin and the transferrin/transferrin receptor complex. Our approach is to use spectroelectrochemical methods to test the hypothesis that Fe³⁺/Fe²⁺ reduction is a critical step in the release of Fe from human-transferrin in the endosome.

Spectroelectrochemical Determination of Transferrin Redox Potentials

See for example:

“Redox Properties of Human Transferrin Bound to its Receptor^”S. Dhungana, C. H. Taboy, O. Zak, M. Larvie, A. L. Crumbliss, and P. Aisen, Biochemistry, 43, 205 (2004).

Last update January 2005
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“Redox Properties of Human Transferrin Bound to its Receptor” S. Dhungana, C. H. Taboy, O. Zak, M. Larvie, A. L. Crumbliss, and P. Aisen, Biochemistry, 43, 205 (2004).

“Redox Properties of Human Transferrin Bound to its Receptor^”S. Dhungana, C. H. Taboy, O. Zak, M. Larvie, A. L. Crumbliss, and P. Aisen, Biochemistry, 43, 205 (2004).