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Siderophore Mediated Iron Bioavailability


Objective: To investigate molecular mechanisms for siderophore mediated Fe acquisition, transport, and storage by microbes. Our approach includes spectroscopic, kinetic and thermodynamic studies of Fe-siderophore and model siderophore complexes, molecular recognition, and membrane transport.

Transferrin: Iron Storage ProteinFerric Binding Protein: A Bacterial TransferrinMolecular RecognitionHemoglobins and Myoglobin: Iron Storage ProteinsSiderophore Mediated Iron Transport: Thermodynamics and Kinetics of Iron Binding

See for example:

 “Iron Chelation Properties of an Extracellular Siderophore Exochelin MS”  S. Dhungana, C. Ratledge, and A. L. Crumbliss, Inorg. Chem., 43, 6274 (2004). 

"Chemical Aspects of Siderophore Mediated Iron Transport" H. Boukhalfa and A. L. Crumbliss, BioMetals, 15, 325 (2002).


Last update February 2005
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