Publications for 2007-2009


  1. Crumbliss, Alvin L.; Harrington, James M., Iron sequestration by small molecules: thermodynamic and kinetic studies of natural siderophores and synthetic model compounds. Advances in Inorganic Chemistry (2009), 61, 179-250.
  2. Harrington, James M.; Crumbliss, Alvin L., The redox hypothesis in siderophore-mediated iron uptake. Biometals (2009), 22(4), 679-689.
  3. Bonaventura, Celia; Henkens, Robert; Weaver, Katherine D.; Alayash, Abdu I.; Crumbliss, Alvin L., Redox reactions of cross-linked haemoglobins with oxygen and nitrite. Protein Reviews (2008), 9(Dioxygen Binding and Sensing Proteins), 79-92.
  4. Tristani, Esther M.; Dubay, George R.; Crumbliss, Alvin L., Characterization of second coordination shell ionophore-siderophore host-guest assemblies and binding selectivities in binary and complex mixtures by electrospray ionization mass spectrometry. Journal of Inclusion Phenomena and Macrocyclic Chemistry (2009), 64(1-2), 57-65.
  5. Dhungana, Suraj; Crumbliss, Alvin L., UV-Vis spectroelectrochemistry of selected iron-containing proteins. Spectroelectrochemistry (2008), 31-67.
  6. Weaver, Katherine D.; Heymann, Jared J.; Mehta, Arnav; Roulhac, Petra L.; Anderson, Damon S.; Nowalk, Andrew J.; Adhikari, Pratima; Mietzner, Timothy A.; Fitzgerald, Michael C.; Crumbliss, Alvin L., Ga3+ as a mechanistic probe in Fe3+ transport: Characterization of Ga3+ interaction with FbpA. Journal of Biological Inorganic Chemistry (2008), 13(6), 887-898.
  7. Flaherty, Meghan M.; Rish, Kimberley R.; Smith, Ann; Crumbliss, Alvin L., An investigation of hemopexin redox properties by spectroelectrochemistry: biological relevance for heme uptake. BioMetals (2008), 21(3), 239-248.
  8. Mies, Kassy A.; Gebhardt, Peter; Moellmann, Ute; Crumbliss, Alvin L., Synthesis, siderophore activity and iron(III) chelation chemistry of a novel mono-hydroxamate, bis-catecholate siderophore mimic: Nα,-Nε-Bis[2,3-dihydroxybenzoyl]-L-lysyl-(γ-N-methyl-N-hydroxyamido)-L-glutamic acid. Journal of Inorganic Biochemistry (2008), 102(4), 850-861.
  9. Roulhac, Petra L.; Weaver, Katherine D.; Adhikari, Pratima; Anderson, Damon S.; DeArmond, Patrick D.; Mietzner, Timothy A.; Crumbliss, Alvin L.; Fitzgerald, Michael C., Ex Vivo Analysis of Synergistic Anion Binding to FbpA in Gram-Negative Bacteria. Biochemistry (2008), 47(14), 4298-4305.
  10. Gebhardt, Peter; Crumbliss, Alvin L.; Miller, Marvin J.; Moellmann, Ute, Synthesis and biological activity of saccharide-based lipophilic siderophore mimetics as potential growth promoters for mycobacteria. BioMetals (2008), 21(1), 41-51.
  11. Dhungana, Suraj; Harrington, James M.; Gebhardt, Peter; Moellmann, Ute; Crumbliss, Alvin L., Iron Chelation Equilibria, Redox, and Siderophore Activity of a Saccharide Platform Ferrichrome Analogue. Inorganic Chemistry (2007), 46(20), 8362-8371.
  12. Bonaventura, Celia; Henkens, Robert; Alayash, Abdu I.; Crumbliss, Alvin L., Allosteric effects on oxidative and nitrosative reactions of cell-free hemoglobins. IUBMB Life (2007), 59(8-9), 498-505.
  13. Anderson, Damon S.; Adhikari, Pratima; Weaver, Katherine D.; Crumbliss, Alvin L.; Mietzner, Timothy A., The Haemophilus influenzae hFbpABC Fe3+ transporter: analysis of the membrane permease and development of a gallium-based screen for mutants. Journal of Bacteriology (2007), 189(14), 5130-5141.
  14. Remington, Nicole; Stevens, Robert D.; Wells, Randall S.; Holn, Aleta; Dhungana, Suraj; Taboy, Celine H.; Crumbliss, Alvin L.; Henkens, Robert; Bonaventura, Celia, Genetic diversity of coastal bottlenose dolphins revealed by structurally and functionally diverse hemoglobins. Gene (2007), 398(1-2), 123-131.
  15. Heymann, J. J.; Weaver, K. D.; Mietzner, T. A.; Crumbliss, A. L., Sulfate as a Synergistic Anion Facilitating Iron Binding by the Bacterial Transferrin FbpA: The Origins and Effects of Anion Promiscuity. Journal of the American Chemical Society (2007), 129(31), 9704-9712.

Select Publications for 2006-2009

  1. Mies, Kassy A.; Wirgau, Joseph I.; Crumbliss, Alvin L..  Ternary complex formation facilitates a redox mechanism for iron release from a siderophore.  Biometals (2006), 19, 115-126.
  2. Dhungana, Suraj; Anderson, Damon S.; Mietzner, Timothy A.; Crumbliss, Alvin L.. Kinetics of Iron Release from Ferric Binding Protein (FbpA): Mechanistic Implications in Bacterial Periplasm-to-Cytosol Fe3+ Transport. Biochemistry (2005), 44(28), 9606-9618.
  3. Dhungana, Suraj; Crumbliss, Alvin L.. Coordination chemistry and redox processes in siderophore-mediated iron transport. Geomicrobiology Journal (2005), 22(3 & 4), 87-98.
  4. Summers, J.S.; Base, K.; Boukhalfa, H.; Payne, J.E.; Shaw, B.R.; Crumbliss, A.L., "Use of Phosphorus Ligand NMR Probes to Investigate Electronic and Second-Sphere Solvent Effects in Ligand Substitution Reactions at Manganese (II) and Manganese (III)", Inorganic Chemistry, (2004), 44 (10) 3405-3411.
  5. Roulhac, Petra L.; Powell, Kendall D.; Dhungana, Suraj; Weaver, Katherine D.; Mietzner, Timothy A.; Crumbliss, Alvin L.; Fitzgerald, Michael C. SUPREX (Stability of Unpurified Proteins from Rates of H/D Exchange) Analysis of the Thermodynamics of Synergistic Anion Binding by Ferric-Binding Protein (FbpA), a Bacterial Transferrin. Biochemistry (2004), 43(50), 15767-15774.
  6. Bonaventura, C.; Crumbliss, A.L.; Weber, R.E., New Insights into the Proton-Dependent Oxygen Affinity of Root Effect Hemoglobins, Acta Physiologica Scandinavica (2004) 182, 245 .
  7. Dhungana, S.; Taboy, C.H.; Zak, O.; Larvie, M.; Crumbliss, A.L.; Aisen, P.; Redox Properties of Human Transferrin Bound to its Receptor. Biochemistry (2004), 43, 205 .
  8. Gabricevic, M.; Anderson, D.S.; Mietzner, T.A.; Crumbliss, A.L.; Kinetics and Mechanism of Iron (III) Complexation by Ferric Binding Protein: The Role of Phosphate. Biochemistry (2004), 43, 5811 .
  9. Dhungana, S.; Ratledge, C.; Crumbliss, A.L., Iron Chelation Properties of an Extracellular Siderophore Exochelin MS. Inorganic Chemistry (2004), 43, 6274 .
  10. Dhungana, S.; Anderson, D.S.; Mietzner, T.A.; Crumbliss, A.L., Phosphate Ester Hydrolysis is Catalyzed by a Bacterial Transferrin: Potential Implications for In Vivo Iron Transport Mechanisms. Journal of Inorganic Biochemistry (2004), 98, 1975.

Select Publications from prior to 2004

Dhungana, S.; Heggemann, S.; Gebhardt, P.; Moellmann U.; Crumbliss, A.L., Fe(III) Coordination Properties of a New Saccharide Based Exocyclic Trihydroxamate Analogue of Ferrichrome. Inorganic Chemistry (2003) 42, 42.

Dhungana, S.; Taboy, C.H.; Anderson, D.S.; Vaughan, K.G.; Aisen, P.; Mietzner, T.A.; Crumbliss, A.L., The Influence of the Synergistic Anion on Iron Chelation by Ferric Binding Protein, A Bacterial Transferrin. Proceedings 0f the National Academy of Science (USA) (2003) 100, 3659. (invited article)

Dhungana, S.; Miller, M.J.; Dong, L.; Ratledge, C.; Crumbliss, A.L.; Iron Chelation Properties of an Extracellular Siderophore Exochelin MN. Journal of the American Chemical Society, (2003) 125, 7654.

Gabricevic, M.; Crumbliss, A.L.; Kinetics and Mechanism of Iron(III)-Nitrilotriacetate Complex Reactions with Phosphate and Acetohydroxamic Acid. Inorganic Chemistry, (2003) 42, 4098.

"The Case of the Missing NO-Hemoglobin: Spectral Changes Suggestive of Heme Redox Reactions Reflect Changes in NO-Heme Geometry" A. Fago, A. L. Crumbliss, J. Peterson, L. L. Pearce and C. Bonaventura, Proc. Natl. Acad. Sci., submitted for publication.

"Carrier Facilitated Bulk Liquid Membrane Transport of Iron(III)-Siderophore Complexes Utilizing First Coordination Sphere Recognition" J. I. Wirgau and A. L. Crumbliss, Inorg. Chem. accepted for publication.

"Synthesis and in vitro Antioxidant Properties of Manganese(III) b-octabromo-meso-tetrakis(4-carboxyphenyl)porphyrin" R. Kachadourian, M. M. Flaherty, A. L. Crumbliss, M. Patel, and B. J. Day, J. Inorg. Biochem., 95, 240 (2003).

"Beryllium(II) Binding to ATP and ADP: Potentiometric Determination of the Thermodynamic Constants and Implications for in vivo Toxicity" H. Boukhalfa, J. G. Lewis and A. L. Crumbliss, BioMetals, accepted for publication.

"Crystal and Molecular Structures of Ionophore-Siderophore Host-Guest Supramolecular Assemblies Relevant to Molecular Recognition" S. Dhungana, P. S. White, and A. L. Crumbliss, J. Am. Chem. Soc., submitted for publication.

"Iron Chelation Properties of an Extracellular Siderophore Exochelin MS" S. Dhungana, C. Ratledge and A. L. Crumbliss J. Biol. Inorg. Chem., submitted for publication.

"Carrier Facilitated Bulk Liquid Membrane Transport of Iron(III) Hydroxamate Complexes Utilizing A Labile Recognition Agent and Amine Recognition in the Second Coordination Sphere" J. I. Wirgau and A. L. Crumbliss, J. Chem. Soc. Dalton Trans., accepted for publication.

"Kinetics and Mechanism of Iron Release from the Bacterial Ferric Binding Protein nFbp: Exogenous Anion Influence and Comparison with Mammalian Transferrin" H. Boukhalfa, D. S. Anderson, T. A. Mietzner and A. L. Crumbliss, J. Biol. Inorg. Chem. submitted for publication.

"Redox Properties of Human Transferrin Bound to its Receptor" S. Dhungana, C. H. Taboy, O. Zak, M. Larvie, A. L. Crumbliss, and P. Aisen, Biochemistry, submitted for publication.