Molecular Recognition

Objective: To investigate the host-guest chemistry of the second coordination sphere of Fe-siderophores and related complexes as it relates to molecular recognition. Our approach includes characterization of new supramolecular assemblies and bulk liquid membrane transport studies.

Ionophore-Siderophore Supramolecular Assemblies


Ferrioxamine B / 18-crown-6	Ferrioxamine B / benzo-18-crown-6	Ferrioxamine B / dicyclohexyl-18-crown-6
Molecular Recognition and Carrier Facilitated Membrane Transport

*flux* = K_ex(D_mem/l)[H_mem][FeL⁺_src][A^-_src]

See for example:

“Crystal and Molecular Structures of Ionophore-Siderophore Host-Guest Supramolecular Assemblies Relevant to Molecular Recognition” S. Dhungana, P. S. White, and A. L. Crumbliss, J. Am. Chem. Soc., 125, 14760 (2003).

“Carrier Facilitated Bulk Liquid Membrane Transport of Iron(III) Hydroxamate Complexes Utilizing A Labile Recognition Agent and Amine Recognition in the Second Coordination Sphere” J. I. Wirgau and A. L. Crumbliss, J. Chem. Soc. Dalton Trans., 3680 (2003).

Last update January 2005
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