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Bacterial Iron Transport (Ferric Binding Protein)

Objective: To investigate the mechanism of ferric binding protein mediated transport of Fe across the periplasmic space of Gram negative pathogens. Our approach is to characterize the coordination chemistry of ferric binding protein, a bacterial transferrin, using spectroscopic, kinetic and thermodynamic techniques.


Proposed Mechanism of Fe Uptake in Gram-Negative Pathogen Neisseria


See for example:

“The Influence of the Synergistic Anion on Iron Chelation by Ferric Binding Protein, A Bacterial Transferrin” S. Dhungana, C. H. Taboy, D. S. Anderson, K. G. Vaughan, P. Aisen, T. A. Mietzner, and A. L Crumbliss, Proc. Natl. Acad. Sci. (USA), 100, 3659 (2003).  

“Kinetics and Mechanism of Iron(III) Complexation by Ferric Binding Protein: The Role of Phosphate”  M. Gabričević,  D. S. Anderson, T. A. Mietzner, and A. L. Crumbliss, Biochemistry, 43, 5811 (2004).


Last update January 2005
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