Event Information
Bioinorganic Investigation of Transferrin Mediated Metal Ion Transport
- Abstract:
Two secondary processes of transferrin (Tf), the human iron transport protein, were investigated: 1) transporting of titanium into the human cell and 2) stealing of iron from Fe2-Tf by pathogenic bacteria. To address the proposed mechanism of titanium transport through the normal Fe2-Tf pathway, we explored the reduction potential of Ti2-Tf. A method was developed to measure the electrochemical properties of metalloproteins with very negative potentials. We also studied the affects on the kinetics of iron release when Fe2-Tf binds to the N. gonorrhoeae receptor (TbpA/TbpB). These bioinorganic studies have implications for the delivery of titanium cancer drugs and the treatment of bacterial infections.
Preliminary Examination Seminar
Student Exams Seminar