Event Information
Enhancement of In Vivo iZQC Signal by Spin Lock Pulse
- Abstract:
Previous applications of intermolecular Zero Quantum Coherence, (iZQC), in MRI have shown their potential to improve soft tissue characterization. However, for most in vivo experiments, the signal to noise ratio, (SNR), obtainable by this means is the most limiting factor. Though the theoretical iZQC signal is 40% of the full equilibrium magnetization, in most in vivo experiments this value drops to only a few percent. For biological samples, the limiting factor is the T2 relaxation, which reduces the signal growth, and ultimately the signal intensity. Therefore, in order to improve the signal intensity of the iZQC signal and enhance the contrast resolution, we propose to modify the standard HOMOGeneity ENhancement by Intermolecular ZEro-quantum Detection, (HOMOGENIZED), pulse sequence. By introducing a spin lock pulse during the rising time of the signal, we can slow down the $T_2$ relaxation process of the spin system and increase the signal amplitude. Computer simulations were used to explore the theoretical underpinning of the optimal modified HOMOGENIZED sequence.
Preliminary Examination Seminar
Student Exams Seminar