Event Information
Tom Wandless
(Stanford University)
A Chemical Approach for Regulating Protein Function
Departmental Seminar
A Chemical Approach for Regulating Protein Function
- Abstract:
- Studies of mammalian development have been revolutionized by the ability to disrupt specific genes using homologous recombination in animals (e.g., knock-out mice). However interpreting the phenotypes of these mice is often difficult due to embryonic lethality or to cellular/molecular compensation for the missing gene during development. By targeting the protein directly rather than its gene, we have developed a general method to regulate the stability (and thus the function) of specific proteins using a synthetic, cell-permeable small molecule. This new technique allows us to rapidly and reversibly eliminate a specific protein either in cell culture or in living mice.
Host: Steve Craig
Departmental Seminar