Event Information
Synthetic Approaches to Switchable Transmembrane Ion Channels
- Abstract:
- Host: Stephen Craig
Abstract: Ion channel proteins play a critical role in many biological signal transduction pathways by facilitating transmembrane ion transport in the presence of specific signals such as transmembrane potential, small molecules, or mechanical deformation. We are interested in mimicking this gated transmembrane ion flow by designing organic macromolecules that span a membrane and can be opened and closed to ion transport using signals such as redox chemistry, light, or chemical modification. The ability to control transmembrane ion flux by means of such well-defined signals has implications for the development of artificial systems capable of performing complex tasks analogous to biological signal transduction. Our strategy involves a two-pronged approach: 1) identify suitable monomolecular transmembrane ion channels, and 2) develop switchable functionality that, when appended to the channel, will alter the channel pore between closed and open states. Progress toward these goals will be presented.
Departmental Seminar