Event Information
Porphyrin-Benzothiadiazole Oligomers in Polymersomes for use as Near-IR Two Photon Imaging Contrast Agents
- Abstract:
Two-photon fluorescence microscopy (TFPM) is often used in deep tissue imaging to provide structural and functional information. In particular, the advantages of using near infrared (NIR) wavelength and exogenous chemicals have been recognized due to negligible autofluorescence, improved imaging depth, and reduced phototoxicity. However, the lack of efficient and safe NIR two-photon dyes prevents the maximal efficacy of using TPFM for deep tissue imaging. Here, we propose to incorporate newly synthesized porphyrin oligomers that show exceptionally high fluorescence quantum yields in the NIR region into biocompatible polymersomes for in-vivo imaging. The two-photon characteristics of these novel nanocomposite systems will be examined as a contrast agent using a two-photon excited fluorescence measurement technique.
Preliminary Examination Seminar
Student Exams Seminar