Recognition and Catalysis in Deep Cavitands
Molecular recognition is the science of weak, intermolecular forces acting on complementary surfaces. This lecture follows the course of research that elaborates synthetic structures with concave surfaces into receptors. These receptors are deep, open-ended cavitands that more or less surround their target molecules. The dynamics of the recognition event and the proper filling of space are presented. Cavitands outfitted with additional functionality are shown to give rise to unusual reactivity. An example of an amine reacting with a receptor bearing an inwardly-directed aldehyde group is shown below.
Host: Steve Craig