Event Information

Mark Stradiotto, Professor (Dalhousie University, Dept. of Chemistry)
Exploiting "DalPhos" Ligands in Challenging Palladium-Catalyzed Cross-Coupling Reactions
Abstract:

My research group has initiated a program employing P,N "DalPhos" ligands as alternatives to more traditional ligand archetypes in palladium-catalyzed C-C and C-N bond-forming reactions; our recent progress in this area will be presented. Notably, the Mor-DalPhos ligand (see graphic) represents the state-of-the-art in the palladium-catalyzed monoarylation of small nucleophilic substrates, including ammonia, hydrazine, and acetone, and has also proven to be highly effective in the gold-catalyzed hydroamination of internal aryl alkynes with dialkylamines. In many cases, the reactions can be performed at relatively low catalysts loadings, with excellent functional group tolerance and chemoselectivity. Preliminary results of coordination chemistry and stoichiometric reactivity studies that seek to provide insight into the behavior of our P,N-ligands in this catalytic chemistry will also be presented.

Host: Ross Widenhoefer

Thursday, April 12, 2012, 11:40am
Chemistry Seminar