Event Information
Synthetic Studies of Bioactive Natural Products
- Abstract:
Research in our group aims to bring the power of modern synthetic organic chemistry to bear on problems in biology and medicine. The main thrust of our current research is developing new synthetic methods and strategies that are applicable in the synthesis of natural products with interesting biological properties. This will be followed by mode of action studies to gain insights to the biological functions of the natural products and the molecular basis of their biological activities.
We recently developed an approach for synthesis of the carbocyclic core of the anti-osteoporotic natural product norzoanthamine based on a transannular Michael reaction cascade. Our study of this transannular process and progresses toward the total synthesis of norzoanthamine will be presented. Our recent synthetic studies of the potent cellular cAMP signaling agonist alotaketal A led to discovery of previously unknown reactivities of alpha,beta-unsaturated N-aryl ketonitrones. These new discoveries constitute the second part of the presentation.
Host: Jiyong Hong
Chemistry Seminar