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Physicochemical Characterization of Chelation and Transport of Iron by Low Molecular Weight Chelators
- Abstract:
The research presented here aims to expand our understanding of the structural factors that contribute to selectivity for iron and to iron complex stability in siderophores, as well as iron transport processes in siderophore systems. This work will also investigate the factors that contribute to therapeutic applications of chelating agents, both for chelation therapy and for antimicrobial agents.
The thermodynamics of iron(III) binding of two synthetic siderophore mimic molecules are determined using pH-dependent spectrophotometric titrations and potentiometric titrations . The thermodynamics of chelation of a number of other natural and synthetic siderophore mimics will also be explored. Also, the redox chemistry of the iron-chelator complexes are investigated using cyclic voltammetry.
Kinetics studies of the iron(III) exchange reactions of some polydentate chelators are presented. The study of the kinetics of some reactions of iron complexes featuring hydroxypyridinone donor-group chelators is performed by spectrophotometric kinetics experiments. A determination of the mechanism of proton-driven complex dissociation of a bishydroxypyridinone siderophore mimic is shown. Also, the mechanism of exchange between desferrioxamine B and an iron(III)-trishydroxypyridinone complex is determined through spectrophotometric monitoring of the reaction. The ability of a bidentate hydroxypyridinone chelator to catalyze the exchange of iron(III) from desferrioxamine B to EDTA is explored and the mechanism is determined.
Ph.D. Dissertation Defense Examination Seminar
Student Exams Seminar