Event Information
Supramolecular Analytical Chemistry
- Abstract:
The use of synthetic and designed receptors for the analysis of complex analytes in real-life settings will be presented. Analytes in beverages, chiral mixtures, and blood/saliva have been targeted by mimicking the mammalian senses of taste and smell. The receptors derive from a combination of rational chemical design and modeling, with combinatorial synthesis techniques. Optical signaling derives either from indicator-displacement, or indicator-uptake, assays. It will be shown that a union of designed receptors targeted to a class of analytes, with combinatorial methods, gives fingerprints that differentiate between the individual members of the class. The strategy is to use a core-binding element that imparts a bias to each and every member of the library, ensuring affinity of the library members for the class of analytes being targeted. The design of this core derives from standard molecular recognition principles: preorganization, complementary, pair-wise interactions between receptor and analyte, and desolvation. Imparting a bias to the affinity of the library members dramatically reduces the diversity space needed in the library. Combinatorial techniques impart the differential behavior and cross-reactivity desired in an array sensing application. The fingerprints of the solutions are created using artificial neural networks, principle component analysis, and/or discriminate analysis. The technique represents a marriage of supramolecular chemistry and pattern recognition protocols.
Host: Michael Therien
Chemistry Seminar