Event Information

Kiyoun Lee (Duke University)
Progress toward the total synthesis of pleurotin and tandem CM / Oxy-SN2Œ for the construction of 2,5-trans-disubstituted tetrahydrofurans and 2,6-cis-disubstituted tetrahydropyransh
Abstract:

Part A : Pleurotin displays antibiotic activity against Gram-positive bacteria and antitumor activity against Erlich ascites carcinoma, L-1210 lymphoid leukemia, and mammary tumors and also highly significant correlation between thioredoxin reductase levels, tumor proliferation, and inhibition of apoptosis.

Part B : Herein this report describes a tandem CM / intramolecular Oxy-SN2Œ protocol that would comprise a new synthetic strategy to facilitate the efficient construction of 2,5-trans-disubstituted tetrahydrofurans and 2,6-cis-disubstituted tetrahydropyrans.

Preliminary Examination Seminar

Wednesday, April 15, 2009, 2:00pm
Student Exams Seminar