Event Information
Inhibition and Specificity Studies on Sortase A, a Transpeptidase from Staphylococcus aureus
- Abstract:
Antibiotic resistance is a crucial issue in modern society. New methods of inhibiting bacterial virulence are essential to creating new treatments. Staphylococcus aureus sortase A is a transpeptidase required for binding virulence factors to the cell wall. While small molecule inhibitors have been synthesized for this enzyme, a non-hydrolyzable or covalently bound inhibitor would be a starting point in learning more about the substrate specificity of the enzyme both inside and around the active site. Potential peptide inhibitors have been synthesized and assayed for activity. While one set of peptides displayed no inhibitory activity, a new set based on a small molecule, phenyl vinyl sulfone, shows promise.
Preliminary Examination Seminar
Student Exams Seminar