Event Information

Ashley Stokes (Duke University)
Multiple Quantum Imaging of Vesicles for Use as Contrast and Carrier Agents
Abstract:

Vesicles have the potential in magnetic resonance imaging (MRI) to provide their own inherent contrast and to protect and deliver other contrast agents, such as hyperpolarized carbon or xenon. For example, liposomes can be detected and tracked in vivo using intermolecular double quantum coherences (iDQCs) in MRI experiments. Here we detect temperature-sensitive liposomes using iDQCs between spins separated by 8 um as potential blood pool imaging agents. The use of iDQC signal at exceedingly short, and previously inaccessible, correlation distances provides a background-free contrast mechanism that allows the selective detection of liposomes.

Preliminary Examination Seminar

Friday, March 6, 2009, 1:30pm
Student Exams Seminar