Event Information

Ceshea Wooten (Duke University)
Part I. Efforts towards the Synthesis of Manassantin A and B
Part II. Synthesis of 2, 5-Diaryl-3, 4-dimethyl Tetrahydrofuran Lignans through Metal Catalyzed Intramolecular Hydroalkoxylation of Un-activated Olefins
Abstract:

Manassantins A and B, natural lignans from the Saururus cernuus L. aquatic plant, have been found to selectively decrease levels of HIF-1. HIF-1 is a transcription factor that plays a role in the Hypoxia pathway and is thought to contribute to cancer by increasing the expression of genes controlling the formation of new blood vessels (angiogenesis), the spread of cancer cells to new sites, and inhibition of programmed cell death (apoptosis). Efforts towards the total synthesis of manassantins A and B are described herein. In addition, development of methodology for the synthesis of 2,5-diaryl-3,4-dimethyl tetrahydrofuran Lignans utilizing metal catalyzed Intramolecular hydroalkoxylation of un-activated olefins is also described.

Preliminary Examination Seminar

Monday, September 24, 2007, 2:00pm
Student Exams Seminar