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Study of the Binding of Synthetic Hydroxypyridinone-donor Siderophores with Iron (III)
- Abstract:
Hydroxypyridinone-donor group (HOPO) siderophore mimics form complexes of high stability with Fe(III) due to their similarity to catechol-donor group siderophores. The pKa’s of the hexadentate tris-hydroxypyridinone ligand, CS224, have been determined spectrophotometrically. Also, the stability of the complexes of two synthetic tetradentate bis-hydroxypyridinone siderophores, CS166 and CS224, with Fe(III) have been measured by spectrophotometric and potentiometric titration and by competition with EDTA. CS224 forms a 1:1 complex with Fe(III) with log β110 = 27.34 ± .04, and CS166 forms a 2:3 complex with Fe(III) with log β230 = 60.46 ± .04. A third HOPO ligand, CS215, was found to be insoluble upon formation of the 2:3 complex with Fe(III). These high formation constants show that hydroxypyridinone ligands may be useful in the development of new chelation therapy agents.
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