Photocleavage of DNA

Jianping Lin

Chemistry 373 Seminar

11/27/2002

Abstract

Photocleavage of DNA is the damage caused by compounds whose excited states can initiate a series of chemical reactions which ultimately lead to nucleic acid cleavage. The sequence selectivity can be improved by using certain photocleave agents such as quinacridine derivatives triggered by triplex formation. Photocleavage is a promising approach for new antitumor and antiviral therapeutic strategies.

Reference

1.Armitage, B., Chem.Rev.1998,98,1171

2. Teulade-Fichou, M.; Perrin, D.; Boutorine, A.; Polverari, D.; Vigneron, J.; Lehn, J.;

Sun, J.; Garestier, T.; Helene, C. J.Am.Chem.Soc. 2001,123,9283

3.Ishikawa, Y.;Yamashita, A.; Uno,T. Chem.Pharm.Bull. 2001,49(3),287

4.Pogozelski, W.K.; Tullius, T.D. Chem.Rev. 1998, 98,1089

5. Meijler,M.M.; Zelenko,O.;Sigman, D.S. J.Am.Chem.Soc.1997,119,1135

6. Burrows, C.J.;Muller, J.G. Chem.Rev. 1998,98,1109

7.Kishikawa,H.;Jiang, P.Y.;Goodisman,J.;Dabrowiak,J.C. J.Am.Chem.Soc. 1991,113,5434