Diverse Functions of Melanocortin Receptors

Valerie R. Kempf
Duke University - Department of Chemistry
Chemistry 373 Seminar
11:50 am, 10/21/02, Room 103



Abstract:

Melanocortin receptors are members of the G-protein coupled receptor class, which display seven transmembrane regions as a hallmark.  To date, five melanocortin receptors have been identified, each having a unique tissue expression pattern.  Sequence variation within these proteins has been linked to diverse physiological roles such as regulating human pigmentation and genetic obesity.  As there are only two endogenous antagonists for the class of G-protein coupled receptors, considerable effort has been put forth to identify novel antagonists to aid in elucidating their biological functions.  Pharmaceutical interests in melanocortin receptors as potential drug targets have increased as more is discovered about them.


 

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